Synthesis, characterization and DNA binding studies of two cyclopentadienyl ruthenium(II) complexes with amino acid ligands

Autor:	Juan Yan, Lin Zhang, Ji-Dong Lou, Min Gao, Juan-Juan Yang, Xiao-Hong Chen, Ping-Sheng Nong, Xiu Lian Lu
Rok vydání:	2010
Předmět:	chemistry.chemical_classification Chemistry Stereochemistry Intercalation (chemistry) Metals and Alloys chemistry.chemical_element Ruthenium Amino acid Inorganic Chemistry chemistry.chemical_compound Cyclopentadienyl complex Bromide Helix Materials Chemistry DNA Organometallic chemistry
Zdroj:	Transition Metal Chemistry. 35:513-519
ISSN:	1572-901X 0340-4285
DOI:	10.1007/s11243-010-9357-y
Popis:	Two new half-sandwich cyclopentadienyl ruthenium(II) complexes containing α-amino acids, [CpRu(PPh3)2(Ser)] (Ser = l-serine) and [CpRu(PPh3)(Met)] (Met = l-methionine), were synthesized and characterized by physicochemical methods. Interactions of these two complexes with calf thymus DNA were investigated by UV–Vis absorption spectroscopy, emission spectroscopy and competitive binding studies. The results indicate that both complexes can interact with DNA, leading to the damage of the double helix. [CpRu(PPh3)2(Ser)] binds to DNA by intercalation, while the binding mode for [CpRu(PPh3)(Met)] is more complicated due to the formation of an EB-DNA-complex (EB = ethidium bromide). The affinity of the Met complex for DNA is stronger than that of the Ser complex, which could be due to groove–surface combination or electrostatic interaction in addition to intercalative binding.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::bb3dd318baca38a0cec7d15ce8c36f24 https://doi.org/10.1007/s11243-010-9357-y Zobrazit plný text záznamu Full text from SpringerLink