A highly diastereoselective synthesis of 3-substituted isoindolin-1-one dericatives

Autor:	Michael I. Page, Steven M. Allin, Christopher J. Northfield, Alexandra M. Z. Slawin
Rok vydání:	1999
Předmět:	chemistry.chemical_classification Stereochemistry Hydride Organic Chemistry Substrate (chemistry) Biochemistry Transition state chemistry.chemical_compound chemistry Drug Discovery Lactam Isoindolin 1 one Triethylsilane Tricyclic
Zdroj:	Tetrahedron Letters. 40:143-146
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(98)80042-7
Popis:	A highly diastereoselective method for the synthesis of 3-substituted isoindolin-1-ones has been developed through application of a tricyclic lactam substrate as an N-acyliminium ion precursor. Ring-opening of the tricyclic lactam with triethylsilane as hydride source generates the targets with up to exclusive levels of diastereoselectivity. This approach compliments that reported in the preceding paper.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::baf810371875aa95f0313f224e545872 https://doi.org/10.1016/s0040-4039(98)80042-7 Zobrazit plný text záznamu Full Text from ScienceDirect