Synthesis and antiischemic activity of dicarboxylic nitroxyalkylamides and nitroxyalkylimides

Autor:	Fedorov Boris S, G. N. Bogdanov, Mikhail A. Fadeev, G. V. Lagodzinskaya
Rok vydání:	2014
Předmět:	Chemistry medicine Organic chemistry General Chemistry Nicorandil Acute toxicity medicine.drug
Zdroj:	Russian Chemical Bulletin. 63:1119-1125
ISSN:	1573-9171 1066-5285
DOI:	10.1007/s11172-014-0558-y
Popis:	A number of dicarboxylic N-(2-nitroxyalkyl)amides and N-(2-nitroxyalkyl)imides were synthesized and their antiischemic activity was studied. The ratio of the areas of necrotic and ischemic zones was used as a criterion for evaluation of antiischemic activity. The maximum values were close to antiischemic activity of Nicorandil, with acute toxicity of compounds synthesized being considerably lower.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::baa4b23d88f3cbfcd55c25035d3f74f5 https://doi.org/10.1007/s11172-014-0558-y Zobrazit plný text záznamu Full text from SpringerLink