Long-Term Effects of Simvastatin in Hypercholesterolemic Patients with NIDDM and Additional Atherosclerotic Risk Factors
| Autor: | Atsushi Ohki, Ino T, M. Amano, Kohji Matsuba, Tsutomu Kazumi, Masato Kasuga, Gen Yoshino |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
medicine.medical_specialty
Apolipoprotein B Endocrinology Diabetes and Metabolism Clinical Biochemistry Blood lipids Biochemistry Bedtime chemistry.chemical_compound Endocrinology Internal medicine medicine Risk factor Glycemic Proteinuria biology Cholesterol business.industry Biochemistry (medical) nutritional and metabolic diseases General Medicine chemistry Simvastatin biology.protein lipids (amino acids peptides and proteins) medicine.symptom business medicine.drug |
| Zdroj: | Hormone and Metabolic Research. 27:239-243 |
| ISSN: | 1439-4286 0018-5043 |
| Popis: | Effects of 12 months of simvastatin treatment were examined in 48 NIDDM patients with total serum cholesterol levels exceeding 220 mg/dl and were compared with those in 35 nondiabetic patients with hypercholesterolemia. In the diabetic group, 5-10 mg of simvastatin given once daily at bedtime significantly lowered total cholesterol (21%). LDL cholesterol (28%), apoB (15%) and triglycerides (8%) levels. These changes were identical to those in the nondiabetic group, except for triglycerides which did not change significantly. HDL cholesterol increased significantly in the nondiabetic group but not in the diabetic group. The reductions in LDL cholesterol and apoB in hypercholesterolemic patients with NIDDM were not influenced by gender, age, glycemic control, the presence or absence of systemic hypertension, obesity and overt proteinuria. In addition, the decrease in LDL cholesterol was not affected by the number of risk factors per patient. Simvastatin did not significantly alter hemoglobin A1c or fasting plasma glucose and was well tolerated in both groups. Simvastatin produced beneficial effects on serum lipids and apolipoproteins and neutral effects on glycemic control in hypercholesterolemic patients with NIDDM, whether or not they had an additional atherosclerotic risk factor. |
| Databáze: | OpenAIRE |
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