2D Magnetic Sensor Array for Real-time Cell Tracking and Multi-site Detection with Increased Robustness and Flow-rate
| Autor: | Xuyang Lu, Suresh Venkatesh, Hooman Saeidi, Gulam M. Rather, Chen-Yong Lin, Hao Tang, Kaushik Sengupta, Mehdi Javanmard, Zhongtian Lin, Joseph R. Bertino |
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| Rok vydání: | 2019 |
| Předmět: |
business.industry
Computer science 020208 electrical & electronic engineering Hardware_PERFORMANCEANDRELIABILITY 02 engineering and technology 021001 nanoscience & nanotechnology Chip Temperature measurement Volumetric flow rate CMOS Sensor array Robustness (computer science) Hardware_INTEGRATEDCIRCUITS 0202 electrical engineering electronic engineering information engineering False positive paradox Cell tracking 0210 nano-technology business Computer hardware |
| Zdroj: | CICC |
| DOI: | 10.1109/cicc.2019.8780363 |
| Popis: | In this article, we present a 2D oscillator array-based magnetic sensor CMOS IC for flow cytometry. The CMOS IC packaged with a microfluidic channel eliminates the need for hydro-focusing by allowing uninhibited flow over the 2D chip surface. The chip exploits multi-site detection capability allowing simultaneously high flow rate for trace cell detection, reduced false positives, and real-time cell tracking. We demonstrate these functionalities with a $7 \times 7$ array in 65-nm CMOS with lymphoma cancer cells. |
| Databáze: | OpenAIRE |
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