Kinetics of relapse after pegylated interferon and ribavirin therapy for chronic hepatitis C

Autor:	Catherine Guillemard, Eric Nguyen-Khac, Etienne Brochot, Gilles Duverlie, Philippe Mathurin, Jean-Christophe Plantier, Ghassan Riachi, Astrid Vabret
Rok vydání:	2013
Předmět:	business.industry Standard treatment Ribavirin Hepatitis C virus Alpha (ethology) medicine.disease_cause Virology chemistry.chemical_compound Infectious Diseases chemistry Pegylated interferon medicine Prospective cohort study Rapid Virologic Response business Viral load medicine.drug
Zdroj:	Journal of Medical Virology. 85:1191-1198
ISSN:	0146-6615
Popis:	To optimize standard treatment of chronic hepatitis C in responder patients who have achieved undetectable viral load, a prospective study was conducted to determine the factors and kinetics of virologic relapse. Responder patients were monitored 2, 4, 8, 12, 16, and 24 weeks after the end of treatment with pegylated interferon and ribavirin. Forty-seven of the 154 patients (30.5%) relapsed. Relapse was significantly associated with absence of rapid virologic response (RVR), retreatment, higher baseline viral load, older age, and lower weight-based dose of pegylated interferon. Relapse was more frequent in patients failing to achieve a RVR after receiving pegylated interferon alpha 2a
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::ba4018d9c79b4c1d1a980e37fc4d8e6b https://doi.org/10.1002/jmv.23592 Zobrazit plný text záznamu Plný text