A phase I study to determine the effect of regorafenib (REG) on the pharmacokinetics (PK) of substrates of P-glycoprotein (P-gp; digoxin) and breast cancer resistant protein (BCRP; rosuvastatin) in patients with advanced solid tumors
| Autor: | S.-E. Al-Batran, Zuzana Jirakova Trnkova, I. Takacs, K. Graudenz, L. Géczi, Dirk Strumberg, I. Sturm, Funan Huang, U. Mueller, Adriaan Cleton |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Digoxin biology business.industry Hematology Pharmacology medicine.disease Phase i study 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology Breast cancer Oncology Pharmacokinetics chemistry Regorafenib medicine biology.protein Rosuvastatin In patient business medicine.drug P-glycoprotein |
| Zdroj: | Annals of Oncology. 27:vi156 |
| ISSN: | 0923-7534 |
| DOI: | 10.1093/annonc/mdw370.23 |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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