High Mean Corpuscular Volume as a Predictor of Poor Overall Survival in Patients with Esophageal Cancer Receiving Concurrent Chemoradiotherapy
| Autor: | Kejie Li, Ping Zhang, Zhenghua Fei, Changlin Zou, Xiaofang Xia, Wen-yue Gu |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Multivariate analysis medicine.diagnostic_test Proportional hazards model business.industry Therapeutic effect Esophageal cancer medicine.disease Gastroenterology Concurrent chemoradiotherapy 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Oncology 030220 oncology & carcinogenesis Internal medicine medicine Overall survival T-stage business Mean corpuscular volume circulatory and respiratory physiology |
| Zdroj: | Cancer Management and Research. 12:7467-7474 |
| ISSN: | 1179-1322 |
| DOI: | 10.2147/cmar.s230274 |
| Popis: | Background Increasing numbers of recent studies have demonstrated that high mean corpuscular volume (MCV) is a predictor of poor overall survival (OS) and therapeutic response in patients with solid tumors. The aim of the present study was to explore the association between high MCV and OS in patients with advanced esophageal cancer (EC) undergoing concurrent chemoradiotherapy. Patients and Methods Enrolled in this study were 249 patients with advanced EC who underwent concurrent chemoradiotherapy. Pre-treatment MCV values were collected in all patients and their correlations with OS and pathophysiological characteristics were analyzed. The chi-square test was used to explore the correlation between MCV and various clinical pathophysiological characteristics, and the prognostic significance of high MCV using Kaplan-Meier curves and the Cox proportional hazards model. All P-values were two-tailed and a P-value 93.6 fL, and 18.8 months in patients with MCV |
| Databáze: | OpenAIRE |
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