4-bromo-1-methoxy-N-[2-(4-aryl-1-piperazinyl)ethyl]-2-naphthalenecarboxamides: Selective dopamine D3 receptor partial agonists
| Autor: | Stephen Joseph Johnson, Shelly A. Glase, Suzanne R. Kesten, Peter J. Manley, Lawrence D. Wise, Jon Wright, Thomas G. Heffner, Thomas A. Pugsley, Robert G. MacKenzie, Hyacinth C. Akunne |
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| Rok vydání: | 1996 |
| Předmět: |
Chemistry
Aryl Organic Chemistry Clinical Biochemistry Pharmaceutical Science Stimulation Pharmacology Biochemistry Partial agonist chemistry.chemical_compound Dopamine receptor D1 Dopamine receptor D3 Dopamine Dopamine receptor D2 Drug Discovery medicine Molecular Medicine Receptor Molecular Biology medicine.drug |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 6:1361-1366 |
| ISSN: | 0960-894X |
| Popis: | A series of 4-bromo-1-methoxy-N-[2-(4-aryl-1-piperazinyl)ethyl]-2-naphthalenecarboxamide dopamine (DA) D 3 receptor agonists has been identified. These compounds were found to be selective for DA D 3 over D 2 receptors and were shown to be partial to full agonists as measured by stimulation of mitogenesis in D 3 -transfected CHO p-5 cells. |
| Databáze: | OpenAIRE |
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