Nanomaterials for in vivo imaging of mechanical forces and electrical fields
| Autor: | Kolbl Rea, Jennifer A. Dionne, Randy D. Mehlenbacher, Alice Lay |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Plasmonic nanoparticles Materials science Nanotechnology Molecular rotors Materials design Biocompatible material Surfaces Coatings and Films Electronic Optical and Magnetic Materials Nanomaterials Biomaterials 03 medical and health sciences 030104 developmental biology Electric field Materials Chemistry Upconverting nanoparticles Preclinical imaging Energy (miscellaneous) |
| Zdroj: | Nature Reviews Materials. 3 |
| ISSN: | 2058-8437 |
| Popis: | Cellular signalling is governed in large part by mechanical forces and electromagnetic fields. Mechanical forces play a critical role in cell differentiation, tissue organization and diseases such as cancer and heart disease; electrical fields are essential for intercellular communication, muscle contraction, neural signalling and sensory perception. Therefore, quantifying a biological system's forces and fields is crucial for understanding physiology and disease pathology and for developing medical tools for repair and recovery. This Review highlights advances in sensing mechanical forces and electrical fields in vivo, focusing on optical probes. The emergence of biocompatible optical probes, such as genetically encoded voltage indicators, molecular rotors, fluorescent dyes, semiconducting nanoparticles, plasmonic nanoparticles and lanthanide-doped upconverting nanoparticles, offers exciting opportunities to push the limits of spatial and temporal resolution, stability, multi-modality and stimuli sensitivity in bioimaging. We further discuss the materials design principles behind these probes and compare them across various metrics to facilitate sensor selection. Finally, we examine which advances are necessary to fully unravel the role of mechanical forces and electrical fields in vivo, such as the ability to probe the vectorial nature of forces, the development of combined force and field sensors, and the design of efficient optical actuators. Mechanical forces and electrical fields are crucial for cellular signalling and can be both inducers and indicators of disease. This Review highlights advances in nanoscale, in vivo, optical probes, discussing spatial and temporal resolution, stability and stimuli sensitivity in bioimaging. |
| Databáze: | OpenAIRE |
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