1656 Biomarkers for Sepsis, Multiple Organ Dysfunction Syndrome (MODS) and Mortality after open Heart Surgery in Children
| Autor: | Aline Medeiros Botta, P Carvalho, Lisiane Dalle Mulle, Cláudia Pires Ricachinevsky, T da Rocha |
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| Rok vydání: | 2012 |
| Předmět: | |
| Zdroj: | Archives of Disease in Childhood. 97:A468-A469 |
| ISSN: | 1468-2044 0003-9888 |
| DOI: | 10.1136/archdischild-2012-302724.1656 |
| Popis: | Background and Aims Biomarkers can help to predict risk of unfavorable outcomes after open heart surgery in children. Methods We performed a retrospective cohort of 121 children after open heart surgery. We analyzed the serum blood lactate, base excess (BE), blood glucose, central venous oxygen saturation (SATvc), troponin I, C-reactive protein (CRP), and leukocyte counts in different postoperative days (POd). Results There were 7.4% deaths, 27.3% of sepsis and 60.3% of MODS. For death, showed better power PO1d and PO2d lactate (OR = 24.1 [CI 4–112]) and (OR = 9.7 [CI 1.2 to 85.7]); PO1d EB (OD = 30.6 [CI 2.6 to 351]); PO1d total leukocytes (OD = 5.8 (1.2 to 29.8]) For sepsis, showed better power: PO6h glucose (OD = 2.4 [1.03 to 5.7]); POI and PO3d SATvc (OD = 2.4 (1.09 to 5.8]) and (OD = 25 6 [2.2–298]); PO6h troponin I (OD = 2.8 [1.1 to 6.8]) and PO1d bastonades (OD = 6.5 [1.4 to 29.6 ]). For MODS, showed better power: PO6h and PO1d SATvc (OD = 12.2 [2.6 to 55.7]) (OD = 2.87 [1.1 to 7.4]) and, POI/PO6h/PO1d troponin-I (OD = 3.2 [1.6 to 8.0]); POI/PO6h CPR (OD = 3.7 [1.3 to 10.8]). Conclusions Blood lactate, base excess, leukocyte count and percentage of bastonades are suitable markers of mortality. Blood glucose, central venous oxygen saturation and cardiac troponin-I are valued predictors of sepsis, and the last two were also reliable markers of MODS and CPR marker only the latter. |
| Databáze: | OpenAIRE |
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