Some aryl semicarbazones possessing anticonvulsant activitie

Autor:	J. W. Quail, SD Tumber, Isabel Rozas, SK Basran, K. K. Sidhu, J. Yang, Mei-Hwa Chen, Jonathan R. Dimmock, Donald F. Weaver
Rok vydání:	1995
Předmět:	Pharmacology animal structures Molecular model Stereochemistry medicine.medical_treatment Aryl Organic Chemistry General Medicine chemistry.chemical_compound Maximal electroshock Anticonvulsant chemistry Drug Discovery Oral route medicine Structure–activity relationship Semicarbazone
Zdroj:	European Journal of Medicinal Chemistry. 30:287-301
ISSN:	0223-5234
Popis:	Summary A number of aryl semicarbazones displayed anticonvulsant activity in the maximal electroshock (MES) and subcutaneous pentylenetetrazole (scPTZ) screens when administered intraperitoneally to mice. When given by the oral route to rats, protection was afforded in the MES but not scPTZ tests. Correlations were noted between the σ and σ * values of the aryl substituents, the interplanar angles made by the aryl rings with the adjacent carbimino groups and the shapes of certain semicarbazones determined by X-ray crystallography, and the activities in the rat oral MES screen. Molecular modeling studies revealed a number of statistically significant descriptors which contributed to anticonvulsant activity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b7bdfaed4610d02c1614f76c6b6c50f0 https://doi.org/10.1016/0223-5234(96)88237-7 Zobrazit plný text záznamu Full Text from ScienceDirect