Feasibility of using deep learning to detect coronary artery disease based on facial photo
| Autor: | Weijian Huang, Jun Pu, Xiang Cheng, Shen Lin, Zhigang Li, Yang Wang, Xi Li, Bai Du, Sipeng Chen, Bo Xu, Bowen Fu, Qi Zhang, Xiantao Song, Yunlong Xia, Yao-Jun Zhang, Xiangyang Ji, Wang Xiaoyi, Zhe Zheng, Bin Lv |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
medicine.diagnostic_test Receiver operating characteristic business.industry CAD 030204 cardiovascular system & hematology medicine.disease Confidence interval Coronary artery disease 03 medical and health sciences Stenosis 0302 clinical medicine Cohort Medicine Outpatient clinic 030212 general & internal medicine Radiology Cardiology and Cardiovascular Medicine business Computed tomography angiography |
| Zdroj: | European Heart Journal. 41:4400-4411 |
| ISSN: | 1522-9645 0195-668X |
| Popis: | Aims Facial features were associated with increased risk of coronary artery disease (CAD). We developed and validated a deep learning algorithm for detecting CAD based on facial photos. Methods and results We conducted a multicentre cross-sectional study of patients undergoing coronary angiography or computed tomography angiography at nine Chinese sites to train and validate a deep convolutional neural network for the detection of CAD (at least one ≥50% stenosis) from patient facial photos. Between July 2017 and March 2019, 5796 patients from eight sites were consecutively enrolled and randomly divided into training (90%, n = 5216) and validation (10%, n = 580) groups for algorithm development. Between April 2019 and July 2019, 1013 patients from nine sites were enrolled in test group for algorithm test. Sensitivity, specificity, and area under the receiver operating characteristic curve (AUC) were calculated using radiologist diagnosis as the reference standard. Using an operating cut point with high sensitivity, the CAD detection algorithm had sensitivity of 0.80 and specificity of 0.54 in the test group; the AUC was 0.730 (95% confidence interval, 0.699–0.761). The AUC for the algorithm was higher than that for the Diamond–Forrester model (0.730 vs. 0.623, P Conclusion Our results suggested that a deep learning algorithm based on facial photos can assist in CAD detection in this Chinese cohort. This technique may hold promise for pre-test CAD probability assessment in outpatient clinics or CAD screening in community. Further studies to develop a clinical available tool are warranted. |
| Databáze: | OpenAIRE |
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