Titanium isopropoxide/pyridine mediated Knoevenagel reactions

Autor:	Brian A. Robichaud, Kevin G. Liu
Rok vydání:	2011
Předmět:	Olefin fiber chemistry.chemical_compound chemistry Organic Chemistry Drug Discovery Condensation Pyridine Aromatic ketones Organic chemistry Knoevenagel condensation Methylene Titanium isopropoxide Biochemistry
Zdroj:	Tetrahedron Letters. 52:6935-6938
ISSN:	0040-4039
Popis:	We report a Ti(OiPr)4/pyridine-mediated Knoevenagel reaction between aromatic ketones and cyanoacetamides to provide Knoevenagel olefin products in good to excellent yields. Almost in all cases studied, a single geometrical isomer was formed and isolated under the Ti(OiPr)4/pyridine condensation conditions. This methodology was also demonstrated to be highly effective between some other Knoevenagel active methylene compounds and aromatic ketones.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b75556ce81647c234bbe18b75b772943 https://doi.org/10.1016/j.tetlet.2011.10.069 Zobrazit plný text záznamu Full Text from ScienceDirect