A CoOOH nanoflake-based light scattering probe for the simple and selective detection of uric acid in human serum
| Autor: | Bin-Cheng Yin, Jian Wang, Yin Hui Wei, Jie Gao, Jia Jun Liu, Zhi Yuan Mao, Xin Yu Li, Lu Ning Zhu |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
chemistry.chemical_classification
Purine Detection limit Chromatography General Chemical Engineering General Engineering 02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Light scattering 0104 chemical sciences Analytical Chemistry chemistry.chemical_compound Allantoin chemistry Linear range Yield (chemistry) Uric acid Nucleotide 0210 nano-technology |
| Zdroj: | Analytical Methods. 10:4951-4957 |
| ISSN: | 1759-9679 1759-9660 |
| DOI: | 10.1039/c8ay01839a |
| Popis: | As a major metabolic product of purine nucleotides, uric acid (UA) usually presents in urine and serum, which is closely related to human health. With the catalysis by uricase, uric acid can yield allantoin, CO2 and H2O2. Then, the produced H2O2 is able to decompose CoOOH nanoflakes into Co2+, resulting in a smaller size with weakened light scattering. This work provides a simple and selective light scattering method for UA analysis with a linear range from 1.0 × 10−5 to 1.0 × 10−3 M and a detection limit of 1.0 × 10−6 M. In addition, this method has been successfully applied to the determination of UA in human serum samples with similar results to clinical methods. |
| Databáze: | OpenAIRE |
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