Dementia patients have greater anti-cholinergic drug burden on discharge from hospital: A multicentre cross-sectional study
| Autor: | H. Boagey, Natalie Ellis, M.-K. Dolley, Judith R. Harrison, K. Bhargava, C. Vinchenzo, A. Zerdelis, B. Sykes, U. Khalid, S. Sehdev, J. Raphael, S. Barai, A. Hook, R. Vaidya, B. Geers, J. Wellington, J. Randall, Q. Lee, C-M. Grubb, D. Codling, M. Maden, A. Hemmad, K. N. Patel, M. Shah, C. Thorburn, D. Asogbon, E. Granger, C. Auty, S. Roche |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Drug
medicine.medical_specialty Anti cholinergic Cross-sectional study business.industry medicine.drug_class media_common.quotation_subject medicine.disease Psychiatry and Mental health Emergency medicine medicine Anticholinergic Dementia In patient Medical prescription Alzheimer's disease business media_common |
| Zdroj: | European Psychiatry. 64:S422-S423 |
| ISSN: | 1778-3585 0924-9338 |
| DOI: | 10.1192/j.eurpsy.2021.1127 |
| Popis: | IntroductionAnticholinergic medications block cholinergic transmission. The central effects of anticholinergic drugs can be particularly marked in patients with dementia. Furthermore, anticholinergics antagonise the effects of cholinesterase inhibitors, the main dementia treatment.ObjectivesThis study aimed to assess anticholinergic drug prescribing among dementia patients before and after admission to UK acute hospitals.Methods352 patients with dementia were included from 17 hospitals in the UK. All were admitted to surgical, medical or Care of the Elderly wards in 2019. Information about patients’ prescriptions were recorded on a standardised form. An evidence-based online calculator was used to calculate the anticholinergic drug burden of each patient. The correlation between two subgroups upon admission and discharge was tested with Spearman’s Rank Correlation.ResultsTable 1 shows patient demographics. On admission, 37.8% of patients had an anticholinergic burden score ≥1 and 5.68% ≥3. At discharge, 43.2% of patients had an anticholinergic burden score ≥1 and 9.1% ≥3. The increase was statistically significant (rho 0.688; p=2.2x10-16). The most common group of anticholinergic medications prescribed at discharge were psychotropics (see Figure 1). Among patients prescribed cholinesterase inhibitors, 44.9% were also taking anticholinergic medications.ConclusionsThis multicentre cross-sectional study found that people with dementia are frequently prescribed anticholinergic drugs, even if also taking cholinesterase inhibitors, and are significantly more likely to be discharged with a higher anticholinergic drug burden than on admission to hospital.Conflict of interestThis project was planned and executed by the authors on behalf of SPARC (Student Psychiatry Audit and Research Collaborative). We thank the National Student Association of Medical Research for allowing us use of the Enketo platform. Judith Harrison was su |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|