Characteristic Changes in the Density and Shear Viscosity of Human Blood Plasma with Varying Protein Concentration
| Autor: | N. P. Malomuzh, A. A. Guslisty, V. Ya. Gotsulskyi, Leonid A. Bulavin |
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| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Ukrainian Journal of Physics. 65:151 |
| ISSN: | 2071-0194 2071-0186 |
| Popis: | The density and shear viscosity of human blood plasma and their dependence on the concentration of proteins (albumin, y-globulin, fibrinogen, etc.) entering the natural blood composition have been studied. The biomaterial concentration is varied by diluting the blood plasma with the isotonic aqueous solution. It is shown that a decrease in the biomaterial concentration down to 0.91 of its initial value leads to a drastic change in the plasma density and to a change in the character of the concentration dependence of the shear viscosity of blood plasma. A hypothesis is put forward that the observed changes in the density and shear viscosity result from the structural transformations induced by oligomerization processes; first of all, by the albumin dimerization. A conclusion is drawn that the introduced blood substitutes should not exceed 10% of the blood mass; otherwise, structural transformations of a biomaterial in blood plasma can be provoked. |
| Databáze: | OpenAIRE |
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