Autor:	Robert P. Clement, Er-jia Wang, Christopher N. Casciano, William W. Johnson
Rok vydání:	2003
Předmět:	Pharmacology biology Organic Chemistry Pharmaceutical Science ATP-binding cassette transporter Drug interaction medicine.disease In vitro chemistry.chemical_compound Cholestasis chemistry Biochemistry medicine biology.protein Molecular Medicine Pharmacology (medical) Binding site Xenobiotic Function (biology) Biotechnology P-glycoprotein
Zdroj:	Pharmaceutical Research. 20:537-544
ISSN:	0724-8741
DOI:	10.1023/a:1023278211849
Popis:	Purpose. Although sister-P-glycoprotein (SPGP, BSEP) is closely related to P-glycoprotein, it is much more selective in distribution and substrate recognition. Moreover, because inhibition or lack of BSEP function has severe consequences including cholestasis, hepatotoxicity, exposure to toxic xenobiotics, and drug interactions, in vitro methods are necessary for quantifying and characterizing specific inhibition of BSEP. Therefore, the objective is to discern a method and quantitatively characterize several example BSEP inhibitors.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b610269d01539764491a861a701b5b6c https://doi.org/10.1023/a:1023278211849 Zobrazit plný text záznamu Full text from SpringerLink