Experimental models of acute liver failure

Autor:	V.S. Rudakov, R V Deev, S.E. Voskanyan, I I Eremin
Rok vydání:	2015
Předmět:	Clinical Practice medicine.medical_specialty Animal model business.industry Experimental model Massive Hepatic Necrosis medicine Liver failure Risk of death Intensive care medicine medicine.disease business Hepatic encephalopathy
Zdroj:	I.P. Pavlov Russian Medical Biological Herald. 23:138-144
ISSN:	2500-2546 0204-3475
DOI:	10.17816/pavlovj20154138-144
Popis:	Acute liver failure is a result of massive hepatic necrosis, accompanied by development of hepatic encephalopathy and can cause multiple organ failure with a high risk of death. Treatment of severe acute liver failure remains the most difficult clinical problem. Reproducible experimental model is required to develop new drugs and strategies of treatment of this pathology. Animal model must be close to clinical practice. This review critically examines many of the models described in the literature and discusses the surrounding issues.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b60803bc959af78dcf9c1c3c298fac1d https://doi.org/10.17816/pavlovj20154138-144 Zobrazit plný text záznamu