Porphyromonas gingivalis infection at different gestation periods on fetus development and cytokines profile
| Autor: | S R R Lucas, S. R. L. Teixeira, Marcia Pinto Alves Mayer, M C A N Michelin, Ellen S. Ando-Suguimoto |
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| Rok vydání: | 2012 |
| Předmět: |
Fetus
Pregnancy biology medicine.medical_treatment Gestational age medicine.disease biology.organism_classification Andrology Cytokine medicine.anatomical_structure Otorhinolaryngology Placenta embryonic structures Immunology medicine Gestation Tumor necrosis factor alpha General Dentistry Porphyromonas gingivalis |
| Zdroj: | Oral Diseases. 18:648-654 |
| ISSN: | 1354-523X |
| DOI: | 10.1111/j.1601-0825.2012.01917.x |
| Popis: | Oral Diseases (2012) 18, 648–654 Aim: Infective agents may affect pregnancy outcomes by deregulating homeostasis. Objectives: The effects of Porphyromonas gingivalis infection before and at different gestation periods were evaluated. Materials and Methods: Wistar rats infected via subcutaneous with P. gingivalis W83, one week before mating (BM), days 1 (PR1) and 11 of gestation (PR11), and controls were evaluated, and samples were obtained at the end of gestation. P. gingivalis was detected by PCR. Cytokine was determined by ELISA. Results: Infected rats had lower maternal gain of weight. Implantation was not observed in 2/12 BM rats. PR11 presented more fetal-placental resorptions and lower placenta/fetus weight than controls. P. gingivalis was detected in placenta and fetus. IL-6 and TNF-α levels were higher in placenta and serum of infected groups, except for TNF-α in placenta of PR1. IL-1β levels were higher in placenta of PR11, but lower in serum and placenta of PR1. There were no differences in IL-10 and PGE2 concentrations among the groups (P |
| Databáze: | OpenAIRE |
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