Pharmacological regulation of opioidergic antinociceptive mechanisms

Autor:	V. N. Zhukov, Yu. Yu. Troyan
Rok vydání:	1991
Předmět:	Opioidergic Chemistry Long-term potentiation General Medicine (+)-Naloxone Pharmacology General Biochemistry Genetics and Molecular Biology Nociception Opioid Anesthesia medicine Morphine Receptor medicine.drug Endogenous opioid
Zdroj:	Bulletin of Experimental Biology and Medicine. 112:1108-1112
ISSN:	1573-8221 0007-4888
DOI:	10.1007/bf00839551
Popis:	Naloxone-depending potentiation of morphine antinociception by some non-opioidergic compounds between different classes of drugs was found in experiments on mice using nociceptive stimuli of different modality. This potentiation can or cannot be bound with elevation of sensitivity of opioid receptors, release of endogenous opioids or destruction of blood-brain barrier function mor morphine peripheral administration. This potentiation named as "release of functional reserve of opioid antinociceptive response" can or cannot be accompanied by an increase of breathing function depression. Taking into account the data of literature about the dissociation of analgetic positive-supporting morphine effects and also the capability of some compounds to lower the narcogenic opiates potential, the supposition about the real possibility of creating combined drugs is made.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b5b9c6022916e3a0b6a5efe7e22762f5 https://doi.org/10.1007/bf00839551 Zobrazit plný text záznamu Full text from SpringerLink