ChemInform Abstract: Preparation of Sulfenyl Pyrroles

Autor:	Alison Thompson, Lana E. Greene, H. Martin Gillis
Rok vydání:	2009
Předmět:	Phthalimides Masking (art) Chemistry Organic chemistry General Medicine Pyrrole derivatives
Zdroj:	ChemInform. 40
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200920095
Popis:	Sulfenyl groups are attracting interest as masking/protectinggroups for pyrroles. A facile one-step synthesis of sulfenyl pyrroles,involving the reaction of pyrroles with N-(aryl-and alkyl-thio)phthalimides in the presence of MgBr 2 ,is reported and the methodology extends to include sulfinyl pyrroles.The one-step procedure gives good yields and is more efficient andpractical than current multistep protocols to sulfenyl pyrrolesthat involve thio-cyanato pyrrolic intermediates. A convenientprocedure for the synthesis of N-(aryl-and alkylthio)phthalimides is also reported.
Databáze:	OpenAIRE
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