Structure elucidation and synthesis of hydroxylated isatins from Streptomycetes
| Autor: | Hartmut Laatsch, Imelda Schuhmann, Vimal Nair, Birger Dittrich, Khaled A. Shaaban, Lei Lei, Elisabeth Helmke, Anja Schüffler, Hnin Yu Win, Mohamed Shaaban |
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| Rok vydání: | 2016 |
| Předmět: | |
| Zdroj: | Zeitschrift für Naturforschung B. 71:1191-1198 |
| ISSN: | 1865-7117 0932-0776 |
| DOI: | 10.1515/znb-2016-0143 |
| Popis: | Chemical investigation of terrestrial and marine streptomycete isolates led to the identification of two new natural pigments, namely, 6-hydroxyisatin (3) and 6-hydroxy-5-methoxyisatin (4). Additionally, the strains delivered numerous known compounds, among them N β -acetyltryptamine, N-acetyltyramine, phenylacetamide, N-(2-phenethyl)acetamide, 1-acetyl-β-carboline, tyrosol, 2′-deoxyadenosine, 2′-deoxythymidine, anthranilic acid, 2′-deoxyuridine, indolyl-3-acetic acid, indolyl-3-carboxylic acid, and p-hydroxybenzoic acid. The isatin structures were deduced by NMR and mass studies and further confirmed by synthesis and by X-ray diffraction of the isomeric 5-hydroxy-6-methoxyisatin (5). |
| Databáze: | OpenAIRE |
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