Structure Determination of N-Methyl-tetrahydro-5H-indazol-5-ones

Autor:	Reddeppareddy Dandu, Kurt A. Josef, Robert L. Hudkins, Ming Tao
Rok vydání:	2006
Předmět:	Methylhydrazine Stereochemistry Chemistry Product (mathematics) General Medicine Nmr data
Zdroj:	ChemInform. 37
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200641106
Popis:	This paper communicates the (regio) synthesis and a convenient NMR structural assignment method for N-methyl-tetrahydro-5H-indazol-5-one isomers. The cyclization reaction of 7-(hydroxymethylene)-1,4-dioxaspiro[4,5]decan-8-one (3) with methylhydrazine yields, after de-protection predominately the N-2 methyl isomer 2. Analysis of the product ratio and structural assignments are based on NMR data including NOE difference experiments and subsequently confirmed with X-ray crystallography. These findings are in sharp contrast with the literature. The experimental conditions used to optimize the synthesis of the individual isomers are discussed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b3c4728719300885b3780e7c232c6546 https://doi.org/10.1002/chin.200641106 Zobrazit plný text záznamu Plný text