Immunomonitoring of patients treated with personalized dendritic cell-based vaccine
| Autor: | Jaroslav Štěrba, Lenka Fědorová, Dalibor Valík, Zdeněk Pavelka, Pavel Mazánek, Lenka Zdražilová Dubská, Regina Demlová, Peter Múdry, Lucie Flajšarová, Kateřina Pilátová, Eva Hlaváčková |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Effector business.industry Hematology Cell-based vaccine Dendritic cell Peripheral blood 3. Good health Vaccination Clinical trial 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Oncology 030220 oncology & carcinogenesis Immunology Medicine Young adult business Ex vivo |
| Zdroj: | Annals of Oncology. 28:xi17 |
| ISSN: | 0923-7534 |
| Popis: | We manufacture fully personalized monocytederived dendritic cell-based vaccines (DC-based vaccines) that are evaluated in investigator- initiated clinical trial “Combined antitumor therapy with ex vivo manipulated dendritic cells producing interleukin-12 in children, adolescents and young adults with progressive, recurrent or primarily metastatic high-risk tumors”. Detailed immunomonitoring of peripheral blood leucocytes subsets at the baseline and during vaccination is performed and includes routine examined peripheral blood parameters, monocyte subsets, MDSC, specific lymphocyte subsets including Tregs, effector Tcells, NKT-like cells. |
| Databáze: | OpenAIRE |
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