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Abstract Background:This study is to investigate the relationship between the Trendelenburg position and regional cerebral oxygen saturation (rSO2) during laparoscopic hysterectomy and possible effects of Dexmedetomidine on cerebral hypoxia of patients undergoing this surgery. Methods: Randomized, prospective and single-blinded study. Patients aged 20 to 65 years are enrolled in this trial,25 in each group. Saline and Dexmedetomidine were infused into petients of Control group and Dexmedetomidine group respectively. Regional cerebral oxygen saturation (rSO2) and hemodynamic parameters were recorded before and after induction of anesthesia and once every 20 min in the Trendelenburg position and 10 min after supine position. We determined prospectively the association of the development of cerebral desaturation and the patient’s position with clinical outcomes of the entire surgery. Results: There was no significant difference between these groups according to demographic characteristics. Right and left rSO2 values of patients in control group decreased at 20 min,40 min and 60 min in the Trendelenburg position, but they increased 10 min after changed to supine position.For Dexmedetomidine group,rSO2 were improved during the Trendelenburg position constantly. The relationship between rSO2 values and cognitive dysfunction was not significant. Conclusion:Dexmedetomidine provides higher rcSO2 values during the Trendelenburg position for laparoscopic hysterectomy. Trial registration: Chinese Clinical Trial Registry. No: ChiCTR1800019174. Prospective registration. Key words: NIRS,rSO2,Trendelenburg position, Dexmedetomidine |
