Iron-catalyzed carbonylation of aryl halides with arylborons using stoichiometric chloroform as the carbon monoxide source

Autor:	Tianjiao Wang, Wei Han, Hongyan Du, Hongyuan Zhao, Xiaorong Yuan
Rok vydání:	2016
Předmět:	Chloroform Aryl radical 010405 organic chemistry Aryl Halide 010402 general chemistry 01 natural sciences Pollution 0104 chemical sciences chemistry.chemical_compound chemistry Environmental Chemistry Organic chemistry Organic synthesis Selectivity Carbonylation Carbon monoxide
Zdroj:	Green Chemistry. 18:5782-5787
ISSN:	1463-9270 1463-9262
DOI:	10.1039/c6gc02158a
Popis:	A general iron-catalyzed carbonylative Suzuki–Miyaura coupling of aryl halides with arylborons is reported, using stoichiometric CHCl3 as the CO source. The high efficiency, economy, selectivity, and operational simplicity of this transformation make this method a valuable tool in organic synthesis. Importantly, the presented strategy allows effective 13C labeling simply by using the commercially available 13C-labeled CHCl3. On the basis of the initial mechanistic exploration, an aryl radical intermediate is proposed in the present carbonylation process.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b2ef6c37c36040e1a0660cbc2a94c581 https://doi.org/10.1039/c6gc02158a Zobrazit plný text záznamu