PECULIARITIES OF ANTIBIOTIC-ASSOCIATED DIARRHEA DEVELOPMENT IN CHILDREN WITH ACUTE RESPIRATORY INFECTIONS
| Autor: | Sergii V. Popov, Oleksandr P Moshchych, Svitlana I Bokova, Olena Kostiantynivna Redko, Svitlana N Kasian, Olena V Savchuk, Oleksandr I Smyian, Viktoriia Oleksandrivna Petrashenko, Andrii Nikolaevich Loboda |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Anamnesis Pediatrics medicine.medical_specialty medicine.drug_class business.industry Incidence (epidemiology) Antibiotics Prevalence Breastfeeding General Medicine Odds ratio Amoxicillin 03 medical and health sciences 030104 developmental biology 0302 clinical medicine 030225 pediatrics medicine Antibiotic-associated diarrhea business medicine.drug |
| Zdroj: | Wiadomości Lekarskie. 72:79-83 |
| ISSN: | 0043-5147 |
| DOI: | 10.36740/wlek201901115 |
| Popis: | Objective Introduction: Acute respiratory infections (ARI) are the main cause of morbidity in most countries. The probability of complications and age determine antibiotics administration. Antibiotic associated diarrhea (AAD) is one of the side effects of antibiotics. The aim: The study of the prevalence rate of AAD and the characteristics of its development in children with ARI. Patients and methods Materials and methods: The study included 75 children aged from 1 to 12 y diagnosed with ARI, who were treated with age-specific doses of antibiotics. The influence of children's anamnesis, parents' health on the development of AAD was studied with odds ratio calculation (OR). Results Results: In general, AAD incidence was 52%. The highest frequency 59.3% was observed in children under 3 y. AAD most often developed in children treated with amoxicillin - 92%. The greatest dependence of AAD development was connected with breastfeeding less than 6 months - OR was 7.65, preterm birth - 2.9, functional GIT disorders in anamnesis - up to 3.14, allergy - 2.33. The risk of AAD development increased with the age of parents more than 35 y - 5.03, at the age of parents less than 18 and older than 35 y - 4.09, parents' allergies - 3.74 and parents smoking - 2.43. Conclusion Conclusions: The most important factors of AAD development on antibiotics therapy in children with ARI are breastfeeding less than 6 months, functional GIT disorders and allergic conditions in anamnesis. Suboptimal age and parents' health (GIT disorders, allergic conditions and unhealthy habits) also increase the risk of AAD development. |
| Databáze: | OpenAIRE |
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