Design, synthesis, and anticancer evaluation of new 1,3,4-oxadiazole thioether derivatives

Autor:	Jaya Shree Anireddy, Naveen Polkam, U. Brahma, G. M. Naidu Vegi, Shankaraiah Malthum
Rok vydání:	2021
Předmět:	chemistry.chemical_compound Thioether chemistry Breast cancer cell line Design synthesis Substituent Oxadiazole Moiety General Chemistry Combinatorial chemistry Human cancer
Zdroj:	Russian Chemical Bulletin. 70:580-584
ISSN:	1573-9171 1066-5285
DOI:	10.1007/s11172-021-3128-0
Popis:	A series of new 1,3,4-oxadiazole derivatives bearing the 2-positioned 2,5-dimethoxyphenyl substituent and 5-positioned organylsulfanyl moiety were designed and synthesized. Screening for anticancer activity against an array of human cancer cells revealed the superior activity of 2-(2,5-dimethoxyphenyl)-5-propylthio-1,3,4-oxadiazole. 2-(2,5-Dimethoxyphenyl)-5-butylthio-1,3,4-oxadiazole displayed excellent activity against breast cancer cell lines.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b26ea6ae3ee8ef9ca48d1d0974edaf4b https://doi.org/10.1007/s11172-021-3128-0 Zobrazit plný text záznamu Full text from SpringerLink