Autor:	E. C. Roos, Quirinus B. Broxterman, Theo Sonke, Eric Mossel, Johan Kamphuis, Marco Crisma, Fernando Formaggio, Claudio Toniolo
Rok vydání:	1998
Předmět:	chemistry.chemical_classification Methyl phenylglycine Triphosgene Stereochemistry medicine.drug_class Antibiotics Biological activity Biochemistry Amino acid Penicillin chemistry.chemical_compound chemistry Ampicillin medicine Chemical stability medicine.drug
Zdroj:	Letters in Peptide Science. 5:43-48
ISSN:	0929-5666
DOI:	10.1023/a:1008806925287
Popis:	Reaction of the N-carboxyanhydride from Cα-methyl d-phenylglycine with either 6-aminopenicillanic acid or 7-amino-3-desacetoxy-cephalosporanic acid furnishes the corresponding ampicillin and cephalexin analogues. Neither the biological activity nor the chemical stability of these new semi-synthetic antibiotics are superior to those of their unmethylated counterparts.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b2597c890f07069787d24c7500f36d21 https://doi.org/10.1023/a:1008806925287 Zobrazit plný text záznamu Full text from SpringerLink