ChemInform Abstract: Synthesis of Pro-Xylane: A New Biologically Active C-Glycoside in Aqueous Media

Autor:	Maria Dalko-Csiba, Christophe Boulle, Louis Ricard, Simon Trouille, Alexandre Cavezza, Patrick Pichaud, Amelie Gueguiniat
Rok vydání:	2009
Předmět:	C glycosides chemistry.chemical_compound Sulfation chemistry Biosynthesis Activator (genetics) Side chain Biological activity General Medicine Xylose Combinatorial chemistry Environmentally friendly
Zdroj:	ChemInform. 40
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200926196
Popis:	The scope and limitation of Lubineau's reaction were evaluated for the synthesis of C-glycosides (compounds 1-13). Further transformation of side chain carbonyl was also achieved (compounds 16-23). Optimization of these two steps was investigated in xylose case. Some of the compounds were shown to stimulate sulfated glycosaminoglycans (GAGs) synthesis. Compound 20 (called Pro-Xylane) was identified as the best activator of GAGs biosynthesis. Pro-Xylane was developed using environmentally friendly conditions relevant to 'Green-Chemistry' principles and launched on the market in September 2006. This compound is the first example of 'Green' chemical used in cosmetic.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b1715e14f39c178dd73a33478e386c94 https://doi.org/10.1002/chin.200926196 Zobrazit plný text záznamu Plný text