Synthesis of novel [1-aziridinyl-(hydroxyimino)methyl]arenes and their cytotoxic activity

Autor:	A. Grigorjeva, Ivars Kalvinsh, V. Andrianov, Ilona Domracheva, Irina Shestakova, E. Yashchenko, Aigars Jirgensons
Rok vydání:	2009
Předmět:	chemistry.chemical_compound Cell culture Chemistry Stereochemistry Organic Chemistry Cytotoxic T cell Aziridine Oxime IC50 In vitro
Zdroj:	Chemistry of Heterocyclic Compounds. 45:161-168
ISSN:	1573-8353 0009-3122
Popis:	The synthesis has been developed for novel potential anticancer agents whose structures contain an aziridine amidoxime group. The cytotoxic activity of all of the target compounds on different cell lines are given together with the in vitro IC50 and LD50 values found. The most promising anticancer agents were found to be the methyl 4-[1-aziridinyl(hydroxyimino)methyl]benzoate, 1-aziridinyl(2-naphthyl)-methanone oxime, and 1-aziridinyl(2-quinolyl)methanone oxime.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b16cbf7259f1fb5a462518a9fa59618f https://doi.org/10.1007/s10593-009-0245-3 Zobrazit plný text záznamu Plný text ve formátu PDF