ADHERENCE TO OPIOID THERAPY IN PATIENTS WITH CHRONIC NON-CANCER PAIN ATTENDING A PAIN CLINIC IN MALAYSIA
| Autor: | Tan H Ling, Munira Izat, Che Suraya Zin, Asween Rowena Abdullah Sani, Abdul Hadi Mohamed, Hussam A. Mizher |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Pharmacology
medicine.medical_specialty business.industry Chronic pain Pharmaceutical Science Worst Possible Pain medicine.disease Dihydrocodeine Fentanyl 03 medical and health sciences 0302 clinical medicine Pain Clinics Opioid 030202 anesthesiology Internal medicine Medicine Pharmacology (medical) business Oxycodone 030217 neurology & neurosurgery medicine.drug Buprenorphine |
| Zdroj: | Asian Journal of Pharmaceutical and Clinical Research. 11:4 |
| ISSN: | 2455-3891 0974-2441 |
| DOI: | 10.22159/ajpcr.2018.v11s3.29960 |
| Popis: | Objectives: This study examined the adherence to opioid therapy in patients with chronic noncancer pain (CNCP). The prevalence of opioid use and pain scores was also explored.Methods: This cross-sectional study was conducted among patients with noncancer pain attending a pain clinic at a tertiary hospital in Malaysia from August 2016 to February 2017. All patients prescribed with any of the five available opioids (morphine, oxycodone, fentanyl, buprenorphine, and dihydrocodeine) were included in the study, and their medical and prescription records were assessed for further information on opioid use such as the type of opioid, dose, frequency, and duration. The prevalence of opioid use was calculated by dividing the number of opioid users and the total number of patients attending the pain clinic during the study. Adherence was calculated for patients with long-term opioid therapy (>90 days/ year) and measured using the medication possession ratio (MPR). This was derived by sum up the total days covered with medication in the last 365 days; and then divide that by the total days, the medication was prescribed over the same period. A cutoff point of 80% or more was considered as adherence. The pain intensity score was assessed through a numerical scale from 0 (no pain) to 10 (worst possible pain) at four different points (now, on average, least in the last 24 h, and worst in the last 24 h).Results: A total of 555 patients with various noncancer pain conditions attended the pain clinic during the study. The prevalence of opioid use among these patients was 13.5% (n=74/555). Of these, 24.3% (n=18/74) of patients using opioids for long term (>90 days) and were included in the adherence measure. 78% (n=14/18) of these long-term opioid users were adherent to opioid therapy with a reported MPR >80%. 22% (n=4/18) of patients showed nonadherence to opioid therapy with a reported MPR |
| Databáze: | OpenAIRE |
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