Synthesis, reactions, antioxidant and anticancer evaluation of some novel coumarin derivatives using ethyl 2-(2-oxo-4-phenyl-2H-chromen-7-yloxy) acetate as a starting material

Autor:	Mohamed Ahmed El-Nassag, Ahmed Halawa, GehadAbd El-Raheem Abd El-Jaleel, Ahmed H. Bedair, Essam M. Eliwa, Mahmoud Mohamed Abd El-All, Ahmed Abd El-Hameed Hassan
Rok vydání:	2014
Předmět:	chemistry.chemical_compound Antioxidant chemistry Stereochemistry medicine.medical_treatment Proton NMR medicine Triazole Oxadiazole Carbon-13 NMR Spectral data Coumarin Cytotoxicity
Zdroj:	European Journal of Chemistry. 5:111-121
ISSN:	2153-2257 2153-2249
DOI:	10.5155/eurjchem.5.1.111-121.860
Popis:	We report on the synthesis of new coumarin derivatives coupled with heterocyclic and bifunctionalized moieties at position 7. The proposed structures were confirmed by correct elemental analysis and spectral data (IR, MS, 1 H NMR and 13 C NMR). Some selected derivatives were also screened for their antioxidant and anticancer activities. The results indicated that 7-{[6-(4-nitrophenyl)-7 H -[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-3-yl]methoxy}-4-phenyl- H -chromen-2-one has the highest antioxidant and anticancer activity in tested compounds.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b1387b2da2e927280deed16775ec0f7b https://doi.org/10.5155/eurjchem.5.1.111-121.860 Zobrazit plný text záznamu