Synthesis, characterization, DNA cleavage, and in-vitro antimicrobial studies of Co(II), Ni(II), and Cu(II) complexes with Schiff bases of coumarin derivatives
| Autor: | Sangamesh A. Patil, Ajaykumar D. Kulkarni, Shrishila N. Unki, Vinod H. Naik, Prema S. Badami |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
biology
Chemistry Ligand Aspergillus niger medicine.disease_cause biology.organism_classification Coumarin Metal chemistry.chemical_compound Deprotonation visual_art Agarose gel electrophoresis Octahedral molecular geometry Polymer chemistry Materials Chemistry medicine visual_art.visual_art_medium Organic chemistry Physical and Theoretical Chemistry Escherichia coli |
| Zdroj: | Journal of Coordination Chemistry. 64:2688-2697 |
| ISSN: | 1029-0389 0095-8972 |
| Popis: | A series of Co(II), Ni(II), and Cu(II) complexes ML · 3H2O have been synthesized with Schiff bases derived from 3-substituted-4-amino-5-mercapto-1,2,4-triazole and 5-formyl-6-hydroxy coumarin. The complexes are insoluble in common organic solvents but soluble in DMF and DMSO. The measured molar conductance values in DMF indicate that the complexes are non-electrolytes. In view of analytical, spectral (infrared, UV-Vis, ESR, TG, and FAB-mass), and magnetic studies, it has been concluded that all the metal complexes possess octahedral geometry in which ligand is coordinated to metal through azomethine nitrogen, phenolic oxygen, and sulfur via deprotonation. The Schiff bases and their complexes have been screened for antibacterial (Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, and Salmonella typhi) and antifungal activities (Aspergillus niger, Aspergillus flavus, and Cladosporium) by the minimum inhibitory concentration method. DNA cleavage is studied by agarose gel electrophoresis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |