Ability of low-molecular heparin (fraxiparine) to counter the action of exogenous coagulases: a fundamental difference from nonfractionated heparin

Autor:	L. P. Tsyvkina, Z. S. Barkagan, S. I. Koltakova
Rok vydání:	1993
Předmět:	Unknown activity biology Chemistry Agkistrodon halys Venom General Medicine Heparin Pharmacology biology.organism_classification complex mixtures General Biochemistry Genetics and Molecular Biology Fraxiparin Echis carinatus Snake venom Fundamental difference medicine medicine.drug
Zdroj:	Bulletin of Experimental Biology and Medicine. 116:1265-1267
ISSN:	1573-8221 0007-4888
DOI:	10.1007/bf00802851
Popis:	A new previously unknown activity of the low molecular-weight heparin Fraxiparin (Sanofi) has been discovered. This is its ability to reduce the plasma clotting action of snake venom coagulases at final concentration of more than 12.5 anti-Xa U/ml, while the unfractionated heparin does not possess this property. The experiments demonstrated that Fraxiparin the action of Echis carinatus prothrombin-activating venom to a greater degree and Agkistrodon halys halys thrombin-like coagulase to a lesser degree. Unlike the unfractionated heparin, Fraxiparan also prevents the death of white rats from acute toxic hemocoagulant shock caused by the intravenous injection of DL100 Echis carinatus venom.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b0e0b7774b75b2e73398b579b2354089 https://doi.org/10.1007/bf00802851 Zobrazit plný text záznamu Full text from SpringerLink