Effect of Substance P and Sar9Met(O2)11-Substance P on Cutaneous Capillary Permeability in Guinea Pig Skin

Autor:	A Barbier, J D Doutremepuich, P Vilain, F Lacheretz
Rok vydání:	1992
Předmět:	Pharmacology medicine.medical_specialty Physiology Chemistry Bradykinin Substance P Vascular permeability Dermatology General Medicine Guinea pig chemistry.chemical_compound Atropine Endocrinology Internal medicine medicine Intradermal injection Histamine Acetylcholine medicine.drug
Zdroj:	Skin Pharmacology and Physiology. 5:171-176
ISSN:	1660-5535 1660-5527
DOI:	10.1159/000211034
Popis:	The purpose of this study was to assess the effect of several drugs on the increase in cutaneous capillary permeability induced by intradermal injection of substance P (SP) and Sar9Met(O2)11-SP in guinea pig skin. On the one hand, the increase in cutaneous capillary permeability was partly reduced by spantide, promethazine, atropine or SR 40037, an inhibitor of the angiotensin-converting enzyme. On the other hand, norepinephrine and B3824, a B2-antagonist of bradykinin, showed an enhancing effect. Our results suggest that the effect of SP and Sar9Met(O2)11-SP in guinea pigs is partly mediated by histamine and acetylcholine, and that there is a relationship between tachykinins and bradykinin.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::aff85fe41484e631a2fc2680b7f932e5 https://doi.org/10.1159/000211034 Zobrazit plný text záznamu