POSSIBLE MECHANISMS OF THYMUS PEPTIDES ANALGESIC ENDPOINT

Autor:	A. V. Novoseletskaya, Nina M. Kiseleva
Rok vydání:	2019
Předmět:	03 medical and health sciences 0302 clinical medicine business.industry Analgesic 030221 ophthalmology & optometry Medicine General Medicine 030204 cardiovascular system & hematology Pharmacology business
Zdroj:	Medical Journal of the Russian Federation. 25:44-48
ISSN:	2412-9100 0869-2106
DOI:	10.18821/0869-2106-2019-25-1-44-48
Popis:	Thymus polypeptides participate in stress-limiting system work. Considering that electropain stimulation is the main stress factor in many behavioral models, it is logical to assume that thymus polypeptides have analgesic activity. The objective of this research is study of opioid and serotoninergic systems role of thymus polypeptides analgesic endpoints implementation. The rats presented with tactivin and thymulin thymus peptides analgesic activity during tail withdrawal test, which is totally blocked by naloxone, and thus is based on opioid system activation. This effect is associated with appeared serotoninergic component of stress-induced analgesia. The possible mechanism of analgesic action and the role of serotoninergic system of thymus peptides were offered based on the results of the research conducted.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::afbcf34d64c17345180d6b6e71401e78 https://doi.org/10.18821/0869-2106-2019-25-1-44-48 Zobrazit plný text záznamu