Parity and osteoporotic fracture risk in postmenopausal women: a dose-response meta-analysis of prospective studies
| Autor: | Qi Wang, Shu-Yun Liu, Xue Gu, Yike Zeng, J.-j. Liang, Junan Liu, Qin Huang |
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| Rok vydání: | 2015 |
| Předmět: |
Gynecology
medicine.medical_specialty Hip fracture business.industry Obstetrics Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism medicine.disease Confidence interval 03 medical and health sciences 0302 clinical medicine Meta-analysis Relative risk Epidemiology medicine 030212 general & internal medicine Risk assessment Prospective cohort study business Live birth |
| Zdroj: | Osteoporosis International. 27:319-330 |
| ISSN: | 1433-2965 0937-941X |
| DOI: | 10.1007/s00198-015-3351-3 |
| Popis: | The present dose-response meta-analysis shows linearly decreased hip fracture (HF) risk and nonlinearly decreased osteoporotic fracture (OF) risk associated with increasing number of parity of up to five live births among postmenopausal women. Epidemiological reports suggest that parity is associated with reduced OF risk among women. However, these findings are controversial. Here, we present a meta-analysis of prospective studies of parity in relation to OF risk. We performed systematic searches using Medline and Embase from January 1, 1966, to December 31, 2014, with limits of language in English and prospective study design. Relative risks (RRs) and confidence intervals (CIs) were derived mainly using random-effects models. Categorical, dose-response, heterogeneity, publication bias, and subgroup analyses were conducted. We analyzed 10 articles of 19 independent reports from 1966 to 2014, comprising a total of 217,295 participants and 26,525 cases of OF. Compared to nulliparous women, the OF and HF risks of parous women with at least one live birth were reduced by 11 % (95 % confidence interval (CI) 3–19 %; I 2 = 77.1 %, p |
| Databáze: | OpenAIRE |
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