ChemInform Abstract: Stereoselective Organocatalytic Synthesis of Oxindoles with Adjacent Tetrasubstituted Stereocenters

Autor:	Helma Wennemers, Oliver D. Engl, Sven P. Fritz
Rok vydání:	2015
Předmět:	Addition reaction biology Stereochemistry Cinchona General Medicine biology.organism_classification Stereocenter Catalysis chemistry.chemical_compound chemistry Organocatalysis Stereoselectivity Derivative (chemistry) Conjugate
Zdroj:	ChemInform. 46
ISSN:	0931-7597
DOI:	10.1002/chin.201538131
Popis:	Both enantiomers of oxindoles with adjacent tetrasubstituted cyclic and acyclic stereogenic centers can be obtained with excellent stereoselectivities by using either a cinchona alkaloid derivative (EDC) as catalyst or Takemoto′s catalyst in conjugate addition reactions of monothiomalonates (II) to isatin-derived N-Cbz ketimines.
Databáze:	OpenAIRE
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