ChemInform Abstract: Synthesis and Anticancer Activity Evaluation of Some Hemin and Hematoporphyrin Derivatives
| Autor: | Sunanada G. Dastidar, Shefali Rajvanshi, Sham M. Sondhi, Monika Johar |
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| Rok vydání: | 2010 |
| Předmět: |
Hematoporphyrin
Drug Stereochemistry Cell growth Melanoma media_common.quotation_subject General Medicine medicine.disease chemistry.chemical_compound medicine.anatomical_structure chemistry DU145 Cell culture Prostate medicine Cancer research skin and connective tissue diseases neoplasms media_common Hemin |
| Zdroj: | ChemInform. 33 |
| ISSN: | 1522-2667 0931-7597 |
| Popis: | Sulphamerazine, sulphadiazine, and sulphaguanidine are coupled with hemin to give bis coupled products la, 1b and 1c respectively. 3, 4-Diphenyl iminothiazoline, sulphamerazine, sulphaacetamide, sulphathiazole and sulphadiazine on coupling with hematoporphyrin give bis coupled products 2a, 2b, 2c, 2d and 2e respectively. Compounds 1a-c and 2a-e have been screened for anticancer activity against a small panel of six cancer cell lines consisting of prostate(DU145), colon (HT29), melanoma (LOX), breast(MCF7 and MCF7/ADR) and CNS(U251) tumors. Best GI 5 0 (concentration which inhibits the cell growth by 50%) values are shown by 2c, 2.2μM(prostate tumor, cell line DU145); 2c 13.0μM(colon tumor, cell line HT29); 2b, 3.4μM(melanoma tumor, cell line LOX); 2c, 9.7μM(breast tumor, cell line MCF7); 2a, 3.1μM(breast, tumor, cell line MCF7/ADR) and 1c, 3.4μM(CNS tumor, cell line U251) respectively. Out of all the compounds reported here GI 5 0 value shown by 2a ι.e.3.1μM against breast, tumor (MCF7/ADR) is quite close to the Gl 5 0 value i.e. 1.8μM, of standard drug doxombicin. |
| Databáze: | OpenAIRE |
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