Bovine Leukocyte Antigen Major Histocompatibility Complex Class IIDRB3*2703andDRB3*1501Alleles Are Associated with Variation in Levels of Protection againstTheileria parvaChallenge following Immunization with the Sporozoite p67 Antigen

Autor:	Keith T. Ballingall, Anthony Luyai, Subash P. Morzaria, G. John Rowlands, Anthony J. Musoke, Declan J. McKeever, Jill Sales
Rok vydání:	2004
Předmět:	biology Theileria parva Immunology Human leukocyte antigen Major histocompatibility complex biology.organism_classification Microbiology Virology Infectious Diseases Antigen Immunization Immunity biology.protein East Coast fever Parasitology Vaccine failure
Zdroj:	Infection and Immunity. 72:2738-2741
ISSN:	1098-5522 0019-9567
DOI:	10.1128/iai.72.5.2738-2741.2004
Popis:	Initial laboratory trials of an experimental subunit vaccine againstTheileria parvabased on the 67-kDa major sporozoite surface antigen revealed a range of responses to challenge. We have analyzed convergence in seven sets of monozygotic twins which suggests that genetic factors may have an influence in determining the degree of protection provided by p67 immunization. In addition, we have examined whether allelic diversity at major histocompatibility complex class II loci influences protection. Analysis of bovine leukocyte antigenDRB3diversity in 201 animals identified significant associations with vaccine success (DRB3*2703;P= 0.027) and vaccine failure (DRB3*1501;P= 0.013). Furthermore,DRB3*2703was associated with the likelihood of immunized animals showing little to no clinical signs of disease following challenge. We discuss the acquired and innate immune mechanisms that may be behind the associations described here.
Databáze:	OpenAIRE
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