Circulating and synovial fluid hyaluronan levels
| Autor: | Robert K. Will, Andrew A. Pitsillides, Michael T. Bayliss, J. C. W. Edwards |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Autoimmune disease
Ankylosing spondylitis medicine.medical_specialty medicine.drug_class business.industry Immunology Albumin Osteoarthritis medicine.disease chemistry.chemical_compound Endocrinology Rheumatology chemistry Rheumatoid arthritis Internal medicine Hyaluronic acid medicine Immunology and Allergy Corticosteroid Synovial fluid Pharmacology (medical) business |
| Zdroj: | Arthritis & Rheumatism. 37:1030-1038 |
| ISSN: | 1529-0131 0004-3591 |
| DOI: | 10.1002/art.1780370708 |
| Popis: | Objective. To assess the effect of intraarticular (IA) corticosteroid on hyaluronan (HA) concentrations in synovial fluid (SF) and serum and the clearance of 131I-labeled albumin from the joints of patients with rheumatoid arthritis (RA), osteoarthritis (OA), and ankylosing spondylitis (AS). Methods. SF and serum were collected before and 2 weeks and 2 months after IA steroid injection. The HA concentration was assessed using an enzyme-linked immunosorbent assay and 131I-albumin clearance from joints was assessed using an external gamma counter. Results. In RA patients, HA concentrations in the SF were increased following IA steroids, while the serum concentrations were decreased. In OA patients, HA concentrations in SF tended to increase initially (decreasing thereafter), and were associated with increased HA concentrations in serum. There were less marked alterations in the AS patients. Albumin clearance rates were decreased significantly (2 weeks postinjection) only in the RA patients. Estimated HA flux revealed discrepancies between the HA concentration and the rate of flux in RA and AS patients. Conclusions. These findings suggest that IA steroid injection is associated with a restoration in the relationship between SF and serum HA concentrations toward normal levels. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text