| Autor: | E. V. Dyatlovitskaya, V. A. Kobliakov, A. G. Kandyba, V. P. Shevchenko, A. M. Kozlov, I. Yu. Nagaev |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
chemistry.chemical_classification
medicine.medical_specialty Ceramide Tumor microenvironment biology General Medicine Dihydroceramide desaturase medicine.disease Biochemistry Molecular biology digestive system diseases Enzyme assay chemistry.chemical_compound Enzyme Endocrinology chemistry Cholangiocellular carcinoma Internal medicine medicine biology.protein Carcinoma Sarcoma |
| Zdroj: | Biochemistry (Moscow). 67:597-599 |
| ISSN: | 0006-2979 |
| DOI: | 10.1023/a:1015562615341 |
| Popis: | Dihydroceramide desaturase activity in the transplantable mouse hepatoma-22, rat hepatoma-27, M1 sarcoma, and RS1 rat cholangiocellular carcinoma has been investigated. It was found that the dihydroceramide desaturase activity in mouse hepatoma-22 is lower than that in normal mouse liver. However, the activity of this enzyme in subcutaneously and intrahepatically transplanted rat hepatoma-27 is increased compared to normal value. Dihydroceramide desaturase activity in subcutaneously and intrahepatically transplanted M1 sarcoma as well as in hepatoma-27 is dependent on the tumor microenvironment. The enzyme activity in RS1 tumor was not revealed. The data indicate that dihydroceramide desaturase activity depends on the tumor type and its microenvironment. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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