Hypoglycemic Activity of Methanolic Extract of Talinum Triagulare Leaves in Normal and Streptozotocin Induced Diabetic Rats
| Autor: | Rama Rao, Prasada Rao, V. Hareesh, R. Ravindra Babu, J. V. Krishna Kanth |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
food.ingredient biology Continuous glucose monitoring business.industry Medicine (miscellaneous) Streptozotocin biology.organism_classification Herbaceous perennial Endocrinology food Mechanism of action Internal medicine Talinum medicine Pharmacology (medical) Talinum triangulare General Pharmacology Toxicology and Pharmaceutics medicine.symptom business Portulacaceae medicine.drug Glipizide |
| Zdroj: | Journal of Applied Pharmaceutical Science. |
| ISSN: | 2231-3354 |
| DOI: | 10.7324/japs.2012.2537 |
| Popis: | Talinum Triangulare (Family: Portulacaceae) is an herbaceous perennial plant widely grown in tropical regions as a leaf vegetable with a blood-glucose-lowering effect, but its mechanism of action are still unknown. Here we report a hypoglycemic activity of Methanolic Extract of Talinum Triangulare Leaf (METTL) in healthy, glucose loaded and Streptozotocin (STZ)-induced diabetic rats. Animals either healthy or STZ-induced diabetic show significantly lowered blood glucose levels after 2 weeks of METTL treatment (250 mg/kg), it significantly reduced blood glucose levels compared with that in diabetic control rats. Additionally, the increase in blood glucose levels after administration of glucose (1.2 g/kg) in normal rats is significantly decreased and the oral glucose tolerance (OGTT) of STZ-induced diabetic rats is largely improved by METTL treatment. However, co-administration of METTL with glipizide, an oral hypoglycemic drug, it produces synergistic effect. We conclude that METTL has a significant anti hyperglycemic effect. Continuous glucose monitoring is needed in diabetic patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|