Metformin-associated lactic acidosis: Moving towards a new paradigm?

Autor: Brandon Walsh, Mark Fineman, Thomas A. Bicsak
Rok vydání: 2017
Předmět:
Zdroj: Diabetes, Obesity and Metabolism. 19:1499-1501
ISSN: 1462-8902
DOI: 10.1111/dom.12994
Popis: The history of Metformin-Associated Lactic Acidosis (MALA) is rooted in the earlier experience with phenformin, another biguanide treatment for type 2 diabetes that was removed from the market owing to a clear causal association with cases of lactic acidosis (LA). Although metformin is less problematic in this regard, metformin can and does induce lactic acidosis, and under the right circumstances it continues to present a potential risk to patients. Recent liberalization of the prescribing guidelines in the US and EU specifically regarding use in more advanced stages of Chronic Kidney Disease (CKD) have led to renewed interest in the topic of MALA, and this issue of the Journal presents two timely articles on the topic by Lalau et al. [1] and Connelly et al. [2].
Databáze: OpenAIRE