DOUBLE BLIND EVALUATION OF LONG ACTING DIETHYLPROPION HYDROCHLORIDE IN OBESE PATIENTS FROM A GENERAL PRACTICE

Autor:	E D Tweddell, D E Carney
Rok vydání:	1975
Předmět:	medicine.medical_specialty business.industry Diethylpropion hydrochloride General Medicine Placebo Crossover study Surgery Double blind Tenuate Dospan Long acting Weight loss Anesthesia General practice medicine medicine.symptom business
Zdroj:	Medical Journal of Australia. 1:13-15
ISSN:	1326-5377 0025-729X
Popis:	Obese patients encountered in general practice were studied in order to determine whether a long-acting form of diethylpropion hydrochloride (Tenuate Dospan) was more effective than placebo for weight loss. One hundred and two patients completed this double blind, 16-week crossover study. During the first eight weeks, the patients treated with diethylpropion hydrochloride lost significantly (P smaller than 0.001) more weight than the patients treated with placebo (an average of 11-1 lb or 6-4% of their initial weight as compared with 6-2 lb or 3-6% of their initial weight). When the group taking diethylpropion hydrochloride crossed over to placebo for a second eight weeks, they lost an average of 1-5 lb (0-9% of their weight at the start of the second period), while the group who crossed from placebo over to diethylpropion hydrochloride lost an average of 6-7 lb (3-8%). The advantages of diethylpropion hydrochloride over placebo are statistically significant.
Databáze:	OpenAIRE
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