P48 Regulation of hydrogen sulfide in digestive stystem

Autor: Ming Wu, Hao Liu, Dan Wang, Yun Ling
Rok vydání: 2014
Předmět:
Zdroj: Nitric Oxide. 39:S30-S31
ISSN: 1089-8603
Popis: Recently, we have studied the pathophysiological significance of H 2 S in the gastrointestinal diseases such as slow transmit constipation, intestinal I/R injury, abdominal infection, and omental arteries of human. We applied in vitro vascular ring tension measurement techniques by the means of measuring the tension of H 2 S and NO effects on human omental arteries ring tension, to reach the aims of exploring Regulation of H 2 S and NO in the blood vessels of adult omentum. The results showed that H 2 S and NO can relaxed human omental arteries with concentration-dependent; We also explore the possible relationship between H 2 S and the pathology of slow transmit constipation. We compound Diphenoxylate to set up the mice models of STC, and recorded the area under the curve (AUC) of spontaneous contractions and contraction frequency after drug additional to study the contraction of colonic tissues in vitro. The evidences showed that H 2 S has an obvious effect on colon smooth muscle contraction, and can increase the intestinal movements in slow transmit constipation. Our experiment states that H 2 S has anti-inflammation effect in prophase of acute peritoneal cavity infection. We used cecal ligation and puncture (CLP) to make up the rat models of acute peritoneal cavity infection, gave them different dispose include giving the donor of H 2 S, then observed the contents of TNF- α and H 2 S in serum and the content of MPO in intestinal tissues. And stated that H 2 S could alleviated CLP-induced inflammation obviously, decreased the content of TNF- α in serum when inflammation, and attenuate the infiltration of neutrophilic granulocyte in small intestine.
Databáze: OpenAIRE
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