Influence of Diallyl disulphide on Hepatic Gluconeogenesis suppression by CREB Binding protein phosphorylation
| Autor: | Kashinath Rt, Ethirajan Sukumar, Prashanthkumar Goudappala |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Glycogen biology Diallyl disulfide Glucose uptake Pharmacology medicine.disease CREB Metformin 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology 0302 clinical medicine chemistry Diabetes mellitus biology.protein medicine Glucose homeostasis General Pharmacology Toxicology and Pharmaceutics CREB-binding protein 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | International Journal of Research in Pharmaceutical Sciences. 10:1327-1331 |
| ISSN: | 0975-7538 |
| DOI: | 10.26452/ijrps.v10i2.536 |
| Popis: | Diabetes is an important human ailment affecting many lives in different countries. Diallyl disulfide (DADS), the antidiabetic compound found in garlic, acts as a therapeutic agent in diabetes mellitus condition. This research aimed to investigate the role of DADS on the gluconeogenic mechanism in the liver tissue and the potential involvement of CREB in glucose homeostasis in a Wistar rat model. The alteration in the body weight, liver weight and glycogen content in diabetic rats were prevented by this therapeutic compound: the cAMP-responsive element-binding protein (CREB), an important transcriptional regulator of the gluconeogenic mechanism. The glucose uptake potential was studied by the expression of CREB protein in DADS treated diabetic rats using the western blotting technique. A high level of hepatic CREB protein expression was noted in diabetic status in the chronic hyperglycemic model which was reversed by DADS. The antihyperglycemic effect of DADS was almost similar to that of known antidiabetic drug metformin. The therapeutic action of DADS on diabetic status is due to the control of the glycemic imbalance in liver tissue. |
| Databáze: | OpenAIRE |
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