Implementation of a treat-to-target strategy in very early rheumatoid arthritis: Results of the Dutch Rheumatoid Arthritis Monitoring remission induction cohort study
| Autor: | Cees J. Haagsma, H.L.M. Brus, Marcel D. Posthumus, Monique Hoekstra, Mart A F J van de Laar, Piet L. C. M. van Riel, Hillechiena H. Kuper, M. Vermeer |
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| Rok vydání: | 2011 |
| Předmět: |
musculoskeletal diseases
medicine.medical_specialty business.industry Immunology medicine.disease Rheumatology Surgery law.invention Clinical trial Randomized controlled trial Interquartile range law Sulfasalazine Internal medicine Rheumatoid arthritis medicine Immunology and Allergy Pharmacology (medical) skin and connective tissue diseases business Rheumatism medicine.drug Cohort study |
| Zdroj: | Arthritis & Rheumatism. 63:2865-2872 |
| ISSN: | 0004-3591 |
| DOI: | 10.1002/art.30494 |
| Popis: | Objective Clinical remission is the ultimate therapeutic goal in rheumatoid arthritis (RA). Although clinical trials have proven this to be a realistic goal, the concept of targeting at remission has not yet been implemented. The objective of this study was to develop, implement, and evaluate a treat-to-target strategy aimed at achieving remission in very early RA in daily clinical practice. Methods Five hundred thirty-four patients with a clinical diagnosis of very early RA were included in the Dutch Rheumatoid Arthritis Monitoring remission induction cohort study. Treatment adjustments were based on the Disease Activity Score in 28 joints (DAS28), aiming at a DAS28 of |
| Databáze: | OpenAIRE |
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